VoiceOver is a built-in screen reader that describes aloud what appears on your computer screen: it speaks the text that’s in documents and windows. Using VoiceOver, you control the computer primarily with a keyboard, braille display, or trackpad, instead of the mouse.
Narrator is a native Window 10 screen reader. It will generally read what is selected or outlined visually on the screen. Use keyboard keys to control Narrator's options and interactivity.